| 2018-01-06 12:30:01January 6, 2018 | Indiana vs Mainline Panthers | 29 - 24 | EHR Main Gym |
| 2018-01-06 13:45:01January 6, 2018 | Berlin Girls vs Mainline Panthers | 7 - 40 | EHR Main Gym |
| 2018-01-13 15:55:01January 13, 2018 | Mainline Panthers vs Forest Hills 6th Grade Girls | 38 - 23 | EHR Aux Gym |
| 2018-01-13 17:00:01January 13, 2018 | Mainline Panthers vs Somerset Trust Co (North Star 6th) | 43 - 5 | EHR Aux Gym |
| 2018-01-20 11:35:01January 20, 2018 | Portage Italian Club vs Mainline Panthers | 40 - 20 | EHR Main Gym |
| 2018-01-20 12:40:01January 20, 2018 | Laurel Kidney DMCA vs Mainline Panthers | 39 - 37 | EHR Main Gym |
| 2018-01-28 16:50:01January 28, 2018 | Mainline Panthers vs Lady Trojans | 50 - 14 | EHR Aux Gym |
| 2018-01-28 17:55:01January 28, 2018 | Mainline Panthers vs Forest Hills Veterinary | 43 - 18 | EHR Aux Gym |
| 2018-02-11 13:35:01February 11, 2018 | Mainline Panthers vs Portage Italian Club | 28 - 30 | EHR Aux Gym |
| 2018-02-11 14:40:01February 11, 2018 | Mainline Panthers vs Indiana | 28 - 33 | EHR Aux Gym |
| 2018-02-17 18:05:01February 17, 2018 | Forest Hills 6th Grade Girls vs Mainline Panthers | 24 - 45 | EHR Aux Gym |
| 2018-02-17 19:05:01February 17, 2018 | Laurel Kidney DMCA vs Mainline Panthers | 34 - 36 | EHR Aux Gym |
| 2018-03-04 17:30:33March 4, 2018 | Mainline Panthers vs Homer Center | 29 - 14 | EHR Main Gym |
| 2018-03-06 18:45:33March 6, 2018 | Horizon (Windber) vs Mainline Panthers | 28 - 43 | EHR Main Gym |
| 2018-03-10 17:15:33March 10, 2018 | Portage Italian Club vs Mainline Panthers | 32 - 35 | EHR Main Gym |
| 2018-03-11 17:00:33March 11, 2018 | Laurel Kidney DMCA vs Mainline Panthers | 27 - 34 | EHR Main Gym |
